PROM overview and general management

E-medicine article about PPROM (June 2011):

pPROM Diagnosis and Management (American Family Physician, Feb. 2006):

Outcomes of expectantly managed preterm premature rupture of membranes occurring before 24 weeks of gestation (Obstet. Gynecol., July 2009)

Expectant Management of pPROM (OBG Management, Oct. 2004):

Evaluation and Management of pPROM (OBG Management, June 2003):

American College of Obstetricians and Gynecologists Guidelines :
June 1998 guidelines
April 2007 guidelines

Survey of pPROM management practices (Am. J. Obstet. Gynecol., Oct. 2004)

Dr. Rose’s Peripheral Brain – PROM:
[for article, click on obstetrics/gynecology, then premature rupture of membranes]


Antibiotic therapy after pPROM (JAMA 1997):

Antibiotic therapy in preterm premature rupture of the membranes (J. Obstet. Gynaecol. Can., Sept. 2009)

Effects of antibiotic therapy after pPROM (Am. J. Perinatology, 2000)

Antibiotics for preterm rupture of membranes (Cochrane Database Syst. Rev., 2003)

Antibiotics for pPROM (Obstet. Gynecol., Nov. 2004)

Vaginal care / preventing infection

Importance of avoiding digital vaginal exams after pPROM (Int. J. Gynaecol. Obstet., May 1990)

Benefits of daily vaginal disinfection (J. Obstet. Gynaeco. Res., Aug. 1998)

Correcting therapies: Amniofusion, Amniopatch

Amnioinfusion general information:

Kentucky Post article – successful amnioinfusion:

Amniopatch to repair second trimester pPROM (Acta. Biomed., 2004):

Abstract of amniopatch article (Clinics in Perinatology):

Amniopatch treatment after amniocentesis-related pPROM (USF Health):

Amniopatch treatment after amniocentesis-related pPROM (Vox Sanguinis, May 2006):

Amniopatch treatment after CVS-related pPROM (Prenat. Diagn., Nov. 2007)


Safety of steroid use (BBC News, Feb. 2005)

Effects of antenatal steroids after pPROM (Aus. N.Z. J. Obstet. Gynaecol., Nov. 1995):

Single vs. Weekly courses of steroids after pPROM (Obstet. Gynecol., Feb. 2004)

Lung development

Beneficial impact of stress hormones after pPROM (Dr., last reviewed Sept. 2010):

Pulmonary Hypoplasia (E-medicine):


Benefits of Vitamin C & E supplementation after pPROM (Int. J. Gynaecol. Obstet., July 2005)


Living through hospital bedrest (Sidelines):

When to deliver

Timing of elective delivery after pPROM (Am. J. Obstet. Gynecol., May 2004)

Optimal gestational age for delivery after pPROM (Obstet. Gynecol., Jan. 2005)

Delivery at 32 or 33 weeks after pPROM (J. Matern. Fetal Neonatal Med., Nov. 2004)

Preemies, NICU, Neonatology

SeeĀ Resources section of Preparing for a PROM Preemie article.

This information was compiled by the members of the PROM list. Nothing on this page should be taken as medical advice. A doctor should be consulted before undertaking any of the medical treatments or methods recommended by the members of the list.

Article by Kay Squires, January 2005, updated July 2011
Special thanks to the members of the PROM list